Durante il tragitto nel bel mezzo di una forte bufera di neve, Bryan investe accidentalmente una misteriosa donna dal comportamento bizzarro. Quello che sembra un banale incidente stradale si rivela essere l'innesco di una catena di eventi incontrollabili: una letale e sconosciuta epidemia biologica inizia a diffondersi rapidamente nella zona, alterando il DNA umano e trasformando la popolazione in mostruose creature mutate
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